Abstract

Chronic wound infections pose significant healthcare challenges due to persistent biofilms, antibiotic resistance, and impaired healing pathways. These wounds are characterized by prolonged inflammation, microbial colonization, and disrupted tissue regeneration, leading to substantial morbidity and healthcare costs. This article reviews current knowledge on chronic wound types, their pathophysiology, and the mechanisms underlying biofilm formation to examine the latest advancements in antimicrobial-based strategies aimed at addressing these challenges. It highlights how diverse materials and technologies have been engineered to improve infection management, enhance tissue regeneration, and overcome the limitations of traditional treatments as well as advances that leverage innovations such as nanotechnology, advanced drug delivery systems, and bioactive components. Furthermore, the review explores how biomaterials can be tailored to interact with the wound microenvironment, mitigating infection risks while accelerating healing. By analyzing the strengths and limitations of these emerging strategies, the review provides insights into the future of chronic wound care by integrating infection biology, biofilm dynamics, diagnostic challenges, and biomaterial-based interventions into a unified framework, highlighting the need for interdisciplinary and strategically layered treatment approaches.

Department(s)

Biological Sciences

Second Department

Chemical and Biochemical Engineering

Publication Status

Full Access

International Standard Serial Number (ISSN)

1524-475X

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2025 Wiley, All rights reserved.

Publication Date

01 Nov 2025

PubMed ID

41292174

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