Abstract
Receptor editing and receptor revision are the two mechanisms of antibody diversity that result in either complete V-gene replacement or the formation of hybrid V genes. We do not yet understand how this process unfolds, because they are rare and difficult to study in vivo. In this study, we describe a family of VH4-34:VH4-61 hybrids isolated from a human B-cell chimeric non-obese diabetic/severe combined immunodeficient mouse. The observation of hybrid immunoglobulin sequences in human B cells that developed in this model system makes it useful for the study of this mechanism of diversification and tolerance.
Recommended Citation
G. R. Kolar and J. D. Capra, "Immunoglobulin Heavy-chain Receptor Editing Is Observed In The NOD/SCID Model Of Human B-cell Development," Scandinavian Journal of Immunology, vol. 60, no. 1, pp. 108 - 111, Wiley, Jul 2004.
The definitive version is available at https://doi.org/10.1111/j.0300-9475.2004.01467.x
Department(s)
Biological Sciences
Publication Status
Free Access
International Standard Serial Number (ISSN)
0300-9475
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Wiley, All rights reserved.
Publication Date
01 Jul 2004
PubMed ID
15238079
Comments
National Institute of Allergy and Infectious Diseases, Grant P01AI045864