Abstract
We have identified a novel mature human B-cell subpopulation in the human tonsil that has characteristics of both naive B cells and germinal center B cells including the expression of activation-induced cytidine deaminase (AID), which is essential for the process of immunoglobulin somatic hypermutation and class-switch recombination. These cells are clearly somatically hypermutated, albeit modestly. Their phenotype (IgD+CD38-CD23 -FSChiCD71+) is unique and suggests they may be intermediate between both naive and germinal center cells. Morphologically they are also distinct from other B-cell subpopulations. The evidence presented suggests these cells may be the founder cells of the germinal center reaction (a pro-GC cell) and may be the normal counterpart of the mantle cell lymphoma cell. © 2007 by The American Society of Hematology.
Recommended Citation
G. R. Kolar et al., "A Novel Human B Cell Subpopulation Representing The Initial Germinal Center Population To Express AID," Blood, vol. 109, no. 6, pp. 2545 - 2552, American Society of Hematology (ASH Publications), Mar 2007.
The definitive version is available at https://doi.org/10.1182/blood-2006-07-037150
Department(s)
Biological Sciences
International Standard Serial Number (ISSN)
0006-4971; 0006-4971
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2025 American Society of Hematology (ASH Publications), All rights reserved.
Publication Date
15 Mar 2007
PubMed ID
17132718
Comments
National Center for Research Resources, Grant P20RR015577