The NOD/SCID Chimeric Mouse Model Of Human B Cell Development: Studies On The VH4 Family Immunoglobulin Repertoire And Implications For SLE
Abstract
The use of the NOD/SCID mouse as a transplant recipient for human cord blood B cell progenitors as a tool for investigations into the development of human B cells has become an exciting reality. The characteristics of the immunoglobulin repertoire in such a model is important to investigate, as it is possible that normal or skewed representations could be produced. Here we review our current work in which we describe a normal VH4 repertoire produced in this chimeric mouse model and describe the differences in combinatorial diversity between the human cells that were isolated from the bone marrow and spleen. The implications of this model for studies of systemic lupus erythematosus are also discussed.
Recommended Citation
G. R. Kolar and J. D. Capra, "The NOD/SCID Chimeric Mouse Model Of Human B Cell Development: Studies On The VH4 Family Immunoglobulin Repertoire And Implications For SLE," Lupus, vol. 12, no. 3, pp. 158 - 162, SAGE Publications, Apr 2003.
The definitive version is available at https://doi.org/10.1191/0961203303lu348xx
Department(s)
Biological Sciences
Keywords and Phrases
Cord blood; Immunoglobulin repertoire; NOD/SCID mice; Systemic lupus erythematosus
International Standard Serial Number (ISSN)
0961-2033
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 SAGE Publications, All rights reserved.
Publication Date
30 Apr 2003
PubMed ID
12708773
