A 5'-upstream Short Open Reading Frame Encoded Peptide Regulates Angiotensin Type 1a Receptor Production and Signalling via the Β-arrestin Pathway

Author

Gina L.C. Yosten, Missouri University of Science and TechnologyFollow
Jun Liu
Hong Ji
Kathryn Sandberg
Robert Speth
Willis K. Samson

Abstract

AUG sequences and short open reading frames are commonly present in the 5'-leader sequence of G protein-coupled receptor mRNAs. The presence of these upstream AUG sequences has been demonstrated to inhibit downstream receptor translation efficiency and, most recently, receptor signal transduction. A seven amino acid peptide encoded by a short open reading frame in exon 2 of the angiotensin type 1a receptor has been shown to inhibit non-G protein-coupled signaling of angiotensin II, without altering the classical G protein-coupled pathway activated by the ligand. This finding may lead to the development of a new class of angiotensin receptor antagonists with activities biased for one, but not all, of the signaling cascades activated by angiotensin II, which could have therapeutic implications for the myriad hormones and neurotransmitters that signal through G protein-coupled receptors.

Recommended Citation

G. L. Yosten et al., "A 5'-upstream Short Open Reading Frame Encoded Peptide Regulates Angiotensin Type 1a Receptor Production and Signalling via the Β-arrestin Pathway," Journal of Physiology, vol. 594, no. 6, pp. 1601 - 1605, Wiley, Mar 2016.

The definitive version is available at https://doi.org/10.1113/JP270567

Department(s)

Biological Sciences

Publication Status

Full Access

Comments

National Institutes of Health, Grant 10GRNT4470043

International Standard Serial Number (ISSN)

1469-7793; 0022-3751

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2025 Wiley, All rights reserved.

Publication Date

15 Mar 2016

PubMed ID

26333095