Nesfatin-1 is a Regulator of Inflammation with Implications During Obesity and Metabolic Syndrome

Author

Tara L. Steffen
Joshua D. Stafford, Missouri University of Science and TechnologyFollow
Willis K. Samson
Gina L.C. Yosten, Missouri University of Science and TechnologyFollow

Abstract

Nesfatin-1, derived from the nucleobindin 2 (NUCB2) precursor, is a potent anorexigenic peptide that was discovered in 2006. Since its identification in the hypothalamus, it has been shown to have wide ranging actions within and outside of the central nervous system. One of these actions is the regulation of inflammation, which could potentially be exploited therapeutically in the context of obesity-associated inflammation in adipose tissue. Here, we review recent advances in our knowledge about the ability of nesfatin-1 to control inflammation by regulating NFκB signaling, which likely attenuates pro-inflammatory cytokine production and inhibits apoptosis.

Recommended Citation

T. L. Steffen et al., "Nesfatin-1 is a Regulator of Inflammation with Implications During Obesity and Metabolic Syndrome," Appetite, vol. 203, article no. 107669, Elsevier, Dec 2024.

The definitive version is available at https://doi.org/10.1016/j.appet.2024.107669

Department(s)

Biological Sciences

Comments

Saint Louis University, Grant None

Keywords and Phrases

Inflammation; Nesfatin-1; NUCB2; Obesity; Peptide

International Standard Serial Number (ISSN)

1095-8304; 0195-6663

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2025 Elsevier, All rights reserved.

Publication Date

01 Dec 2024

PubMed ID

39251090