Abstract
Adropin, a recently described peptide hormone produced in the brain and liver, has been reported to have physiologically relevant actions on glucose homeostasis and lipogenesis, and to exert significant effect on endothelial function. We describe a central nervous system action of adropin to inhibit water drinking and identify a potential adropin receptor, the orphan G protein-coupled receptor, GPR19. Reduction in GPR19 mRNA levels in medial basal hypothalamus of male rats resulted in the loss of the inhibitory effect of adropin on water deprivation-induced thirst. The identification of a novel brain action of adropin and a candidate receptor for the peptide should extend and accelerate the study of the potential therapeutic value of adropin or its mimetics for the treatment of metabolic disorders.
Recommended Citation
L. M. Stein et al., "Adropin Acts in Brain to Inhibit Water Drinking: Potential Interaction with the Orphan G Protein-coupled Receptor, GPR19," American Journal of Physiology Regulatory Integrative and Comparative Physiology, vol. 310, no. 6, pp. R476 - R480, American Physiological Society, Mar 2016.
The definitive version is available at https://doi.org/10.1152/ajpregu.00511.2015
Department(s)
Biological Sciences
Publication Status
Open Access
Keywords and Phrases
Adropin; G protein-coupled receptor; Hypothalamus; Thirst
International Standard Serial Number (ISSN)
1522-1490; 0363-6119
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2025 American Physiological Society, All rights reserved.
Creative Commons Licensing
This work is licensed under a Creative Commons Attribution 4.0 License.
Publication Date
01 Mar 2016
PubMed ID
26739651
Comments
National Institutes of Health, Grant R01HL121456