Abstract
Cocaine- and amphetamine-regulated transcript encodes an eponymous peptide, CARTp, which exerts diverse pharmacologic actions in the central and peripheral nervous systems, as well as in several endocrine organs, including pancreas. Here we review those diverse actions, the physiological relevance of which had remained unestablished until recently. With the identification of a CARTp receptor, GPR160, the physiologic importance and therapeutic potential of CARTp or analogs are being revealed. Not only is the CARTp-GPR160 interaction essential for the circadian regulation of appetite and thirst but also for the transmission of nerve injury-induced pain. Molecular approaches now are uncovering additional physiologically relevant actions, and the development of acute tissue-specific gene compromise approaches may reveal even more physiologically relevant actions of this pluripotent ligand/receptor pair.
Recommended Citation
W. K. Samson et al., "Overcoming Stress, Hunger, and Pain: Cocaineand Amphetamine-regulated Transcript Peptide's Promise," Endocrinology United States, vol. 162, no. 8, article no. bqab108, Oxford University Press; Endocrine Society, Aug 2021.
The definitive version is available at https://doi.org/10.1210/endocr/bqab108
Department(s)
Biological Sciences
Publication Status
Free Access
Keywords and Phrases
Addiction; Allodynia; Obesity; Satiation; Vagus nerve
International Standard Serial Number (ISSN)
1945-7170; 0013-7227
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Oxford University Press; Endocrine Society, All rights reserved.
Publication Date
01 Aug 2021
PubMed ID
34043767
Comments
National Institute of Neurological Disorders and Stroke, Grant R01NS113257