Abstract
Nesfatin-1 is a recently discovered hypothalamic peptide that was shown to suppress food intake through a melanocortin-3/4 receptor-dependent mechanism. Since nesfatin-1 mRNA is detected in the paraventricular nucleus of the hypothalamus, and because many peptides that alter food intake also influence cardiovascular function, we tested the ability of centrally administered nesfatin-1 to affect mean arterial pressure (MAP) in conscious, freely moving rats. Significant increases in MAP were observed following intracerebroventricular administration of nesfatin-1. Pretreatment with either the melanocortin-3/4 receptor antagonist, SHU9119 (intracerebroventricular), or the α-adrenergic antagonist, phentolamine (intra-arterial), abrogated the rise in MAP induced by nesfatin-1, indicating that nesfatin-1 may interact with the central melanocortin system to increase sympathetic nerve activity and lead to an increase in MAP. Thus, we have identified a novel action of nesfatin-1, in addition to its anorexigenic effects, to stimulate autonomic nervous system activity. Copyright © 2009 the American Physiological Society.
Recommended Citation
G. L. Yosten and W. K. Samson, "Nesfatin-1 Exerts Cardiovascular Actions in Brain: Possible Interaction with the Central Melanocortin System," American Journal of Physiology Regulatory Integrative and Comparative Physiology, vol. 297, no. 2, pp. R330 - R336, American Physiological Society, Aug 2009.
The definitive version is available at https://doi.org/10.1152/ajpregu.90867.2008
Department(s)
Biological Sciences
Publication Status
Open Access
Keywords and Phrases
Appetite; Autonomics; Hypothalamus
International Standard Serial Number (ISSN)
1522-1490; 0363-6119
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2025 American Physiological Society, All rights reserved.
Creative Commons Licensing
This work is licensed under a Creative Commons Attribution 4.0 License.
Publication Date
01 Aug 2009
PubMed ID
19474390
Nesfatin-1 Exerts Cardiovascular Actions In Brain_ Possible Interaction With The Central Melanocortin System______Sup 2.pdf (267 kB)
Nesfatin-1 Exerts Cardiovascular Actions In Brain_ Possible Interaction With The Central Melanocortin System______Sup 3.pdf (192 kB)
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Comments
National Heart, Lung, and Blood Institute, Grant R01HL066023