Cardiovascular and Antidipsogenic Effects of Nesfatin-1
Abstract
Nesfatin-1, derived from the nucleobindin-2 gene product, is expressed in neurons located in brain centers known to be important in the central regulation of both cardiovascular function and fluid and electrolyte homeostasis. In fact the peptide colocalizes in those neurons with an impressive list of neuropeptides and neurotransmitters known to be important in the regulation of thirst, appetite and central autonomic control. We and others have demonstrated potent sympatho-stimulatory actions of nesfatin-1 in brain and the potential physiologic relevance of those effects. In addition, although nesfatin-1 was originally described as a peptide with potent anorexigenic actions in brain, effects corroborated by several groups, it is possible that the anorexigenic actions of nesfatin-1 are secondary to a primary action to reduce thirst. Progress in unraveling the importance of endogenous nesfatin-1 in cardiovascular function, or fluid and electrolyte homeostasis, has been limited due to the to date unavailability of nesfatin-1 antagonists and the fact that the receptor for nesfatin-1 remains unidentified. © 2013 Bentham Science Publishers.
Recommended Citation
G. L. Yosten and W. K. Samson, "Cardiovascular and Antidipsogenic Effects of Nesfatin-1," Current Pharmaceutical Design, vol. 19, no. 39, pp. 6973 - 6975, Bentham Science Publishers, Dec 2013.
The definitive version is available at https://doi.org/10.2174/138161281939131127142720
Department(s)
Biological Sciences
Keywords and Phrases
Appetite; Arterial pressure; Hypothalamus; Medulla; Sympathetic nervous system; Thirst
International Standard Serial Number (ISSN)
1873-4286; 1381-6128
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Bentham Science Publishers, All rights reserved.
Publication Date
01 Dec 2013
PubMed ID
23537087
Comments
National Institute of General Medical Sciences, Grant T32GM008306