The Anti-Biofilm Efficacy of Copper and Zinc Doped Borate Bioactive Glasses

Abstract

Aim: Healthcare-acquired infections (HAIs) pose significant challenges in medical settings due to their resistance to conventional treatment methods. The role of bacterial biofilms in exacerbating these infections is well-documented, making HAIs particularly difficult to eradicate. Despite numerous research efforts, an effective solution to combat these infections remains elusive. This study aims to explore the potential of metal-ion (copper and zinc) doped borate bioactive glasses (BBGs) as a novel treatment modality to inhibit bacterial species commonly implicated in HAIs: Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa. Methods: The study analyzed the efficacy of both direct and indirect applications of BBGs on severe biofilms pre-formed under static and dynamic growth conditions; a comprehensive predictive modeling was developed, simulating diverse clinically relevant conditions. Results: Results demonstrate more than 4 log reduction in bacterial growth within 2 days for direct application and 3 days for indirect application of copper and zinc-doped BBGs. These findings were consistent across the three bacterial species, in both static and dynamic conditions. Conclusion: Copper and zinc-doped BBGs can be an effective approach in combating HAIs complicated by biofilms.

Department(s)

Biological Sciences

Second Department

Chemical and Biochemical Engineering

Keywords and Phrases

biofilm; borate bioactive glass; copper; GL1605; healthcare-acquired infection; MIRRAGEN; zinc

International Standard Serial Number (ISSN)

1746-0921; 1746-0913

Document Type

Article - Journal

Document Version

Final Version

File Type

text

Language(s)

English

Rights

© 2024 The Authors, All rights reserved.

Creative Commons Licensing

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

Publication Date

01 Jan 2024

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