Cell-Penetrating Peptides for Medical Theranostics and Targeted Drug Delivery
Abstract
We focus on three major topics in this chapter. First, we describe cellular uptake mechanisms of cell-penetrating peptides (CPPs). The pitfalls and complementary tools in conducting mechanistic studies of uptake are illustrated. Second, we depict applications of two powerful CPPs, activatable cell-penetrating peptides (ACPPs) and tumor internalizing RGD (iRGD) peptides, for medical imaging and drug delivery. A combinational approach with CPPs and the clustered regularly interspaced short palindromic repeats (CRISPR)- associated (Cas) protein 9 (CRISPR-Cas9) system may provide an alternative for gene delivery and editing. Lastly, we review the safety and biocompatibility of CPPs in medical applications.
Recommended Citation
Y. Huang and H. Lee, "Cell-Penetrating Peptides for Medical Theranostics and Targeted Drug Delivery," Peptide Applications in Biomedicine, Biotechnology and Bioengineering, pp. 359 - 370, Elsevier, Jan 2018.
The definitive version is available at https://doi.org/10.1016/B978-0-08-100736-5.00013-2
Department(s)
Biological Sciences
Keywords and Phrases
Cell-Penetrating Peptide; Cellular Uptake Mechanisms; Targeted Drug Delivery and Genome Editing
International Standard Book Number (ISBN)
978-0-0810-0742-6; 978-0-0810-0736-5
Electronic OCLC #
1008764675
Print OCLC #
1043415906
Document Type
Book - Chapter
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2018 Elsevier, All rights reserved.
Publication Date
01 Jan 2018
