Energetic Basis of Correlation Between Catch-Up Growth, Health Maintenance, and Aging
Catch-up growth, referring to infants with low birth weight reaching or exceeding normal body weight later in life, is negatively correlated to adult health outcome and life span. Life history theories have suggested that there exist trade-offs between early development and later health maintenance, but detailed mechanisms and the currency of the trade-off are unclear. In this paper, we present a general theoretical model for quantitatively elucidating the trade-off between growth rate and health maintenance in mammals from an energetic viewpoint. Based on the fundamental principles of energy conservation and organisms ' energy budgets, our model analyzes the allocation of metabolic energy to growth and health maintenance in different sets of pre natal and post natal environments. Our model also implies a relationship between growth rate and the general process of aging. Life-span predictions are supported by quantitative and qualitative empirical observations and offer theoretical frameworks for future experimental designs and data analyses.
C. Hou et al., "Energetic Basis of Correlation Between Catch-Up Growth, Health Maintenance, and Aging," Journals of Gerontology, Series A, vol. 66 A, no. 6, pp. 627 - 638, Oxford University Press, Jun 2011.
The definitive version is available at https://doi.org/10.1093/gerona/glr027
Ellison Medical Foundation
National Institutes of Health (U.S.)
Keywords and Phrases
Aging; Catch-Up Growth; Energy Trade-Off; Health Maintenance
International Standard Serial Number (ISSN)
Article - Journal
© 2011 Hou et al., All rights reserved.
01 Jun 2011