Inducing Sleep by Remote Control Facilitates Memory Consolidation in Drosophila
Sleep is believed to play an important role in memory consolidation. We induced sleep on demand by expressing the temperature-gated nonspecific cation channel Transient receptor potential cation channel (UAS-TrpA1) in neurons, including those with projections to the dorsal fan-shaped body (FB). When the temperature was raised to 31°C, flies entered a quiescent state that meets the criteria for identifying sleep. When sleep was induced for 4 hours after a massed-training protocol for courtship conditioning that is not capable of inducing long-term memory (LTM) by itself, flies develop an LTM. Activating the dorsal FB in the absence of sleep did not result in the formation of LTM after massed training.
J. Donlea et al., "Inducing Sleep by Remote Control Facilitates Memory Consolidation in Drosophila," Science, vol. 332, no. 6037, pp. 1571 - 1576, American Association for the Advancement of Science (AAAS), Jun 2011.
The definitive version is available at https://doi.org/10.1126/science.1202249
Keywords and Phrases
Galactosidase; Galactosidase 4; Transient Receptor Potential Channel; Unclassified Drug, Cation; Control System; Courtship; Fly; Learning; Memory; Neurology; Remote Sensing; Sleep; Temperature Effect, Animal Cell; Animal Experiment; Article; Brain Region; Drosophila; Locomotion; Long Term Memory; Memory Consolidation; Motor Activity; Nerve Cell; Nonhuman; Priority Journal; Protein Expression; Sleep Induction; Wakefulness, Animals; Conditioning (Psychology); Drosophila; Drosophila Proteins; Female; Memory, Long-Term; Models, Animal; Motor Activity; Neurons; Presynaptic Terminals; Sleep; Social Isolation; Temperature; Transcription Factors; Transient Receptor Potential Channels
International Standard Serial Number (ISSN)
Article - Journal
© 2011 American Association for the Advancement of Science (AAAS), All rights reserved.
01 Jun 2011