Inducing Sleep by Remote Control Facilitates Memory Consolidation in Drosophila

Abstract

Sleep is believed to play an important role in memory consolidation. We induced sleep on demand by expressing the temperature-gated nonspecific cation channel Transient receptor potential cation channel (UAS-TrpA1) in neurons, including those with projections to the dorsal fan-shaped body (FB). When the temperature was raised to 31°C, flies entered a quiescent state that meets the criteria for identifying sleep. When sleep was induced for 4 hours after a massed-training protocol for courtship conditioning that is not capable of inducing long-term memory (LTM) by itself, flies develop an LTM. Activating the dorsal FB in the absence of sleep did not result in the formation of LTM after massed training.

Department(s)

Biological Sciences

Keywords and Phrases

Galactosidase; Galactosidase 4; Transient Receptor Potential Channel; Unclassified Drug, Cation; Control System; Courtship; Fly; Learning; Memory; Neurology; Remote Sensing; Sleep; Temperature Effect, Animal Cell; Animal Experiment; Article; Brain Region; Drosophila; Locomotion; Long Term Memory; Memory Consolidation; Motor Activity; Nerve Cell; Nonhuman; Priority Journal; Protein Expression; Sleep Induction; Wakefulness, Animals; Conditioning (Psychology); Drosophila; Drosophila Proteins; Female; Memory, Long-Term; Models, Animal; Motor Activity; Neurons; Presynaptic Terminals; Sleep; Social Isolation; Temperature; Transcription Factors; Transient Receptor Potential Channels

International Standard Serial Number (ISSN)

0036-8075;1095-9203

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2011 American Association for the Advancement of Science (AAAS), All rights reserved.

Publication Date

01 Jun 2011

PubMed ID

21700877

Link to Full Text

Share

 
COinS