Abstract
Excessive daytime sleepiness (EDS) is a ubiquitous problem that affects public health and safety. A test that can reliably identify individuals that suffer from EDS is needed. In contrast to other methods, salivary biomarkers are an objective, inexpensive, and noninvasive method to identify individuals with inadequate sleep. Although we have previously shown that inflammatory genes are elevated in saliva samples taken from sleep deprived individuals, it is unclear if inflammatory genes will be elevated in clinical populations with EDS. In this study, salivary samples from individuals with sleep apnea were evaluated using the Taqman low density inflammation array. Transcript levels for 3 genes, including prostaglandin-endoperoxide synthase 2 (PTGS2), were elevated in patients with sleep apnea. Interestingly, PTGS2 was also elevated in patients with EDS but who did not have sleep apnea. These data demonstrate the feasibility of using salivary transcript levels to identify individuals that self-report excessive daytime sleepiness.
Recommended Citation
M. S. Thimgan et al., "Excessive Daytime Sleepiness Is Associated with Changes in Salivary Inflammatory Genes Transcripts," Mediators of Inflammation, vol. 2015, Hindawi Publishing Corporation, Jan 2015.
The definitive version is available at https://doi.org/10.1155/2015/539627
Department(s)
Biological Sciences
International Standard Serial Number (ISSN)
0962-9351;1466-1861
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2015 Thimgan et al., All rights reserved.
Creative Commons Licensing
This work is licensed under a Creative Commons Attribution 4.0 License.
Publication Date
01 Jan 2015
PubMed ID
25873764
Comments
This work was supported by NIMH HL092731.