Abstract
The electrophoretic transport of three chemically reacting species, two of which can bind reversibly to form the third, is analyzed mathematically. The species are assumed to move horizontally through a long channel with different electrophoretic mobilities and diffusion coefficients. By considering small perturbations of the system about equilibrium or when one of the two binding species is much more abundant than the other, the governing advection-reaction- diffusion equations can be linearized and studied via the method of moments. The result is a set of coupled ordinary differential equations for the moments that can be solved analytically. Analysis of the long-time evolution of the moments yields mean velocities and dispersion coefficients for each species. The results provide a method for measuring the rate and equilibrium constants of binding reactions using capillary electrophoresis. © 2007 The American Physical Society.
Recommended Citation
Daneshbod, Y., Sterling, J. D., & Nadim, A. (2007). Moment Analysis Of Near-equilibrium Binding Interactions During Electrophoresis. Physical Review E Statistical Nonlinear and Soft Matter Physics, 76(5) American Physical Society.
The definitive version is available at https://doi.org/10.1103/PhysRevE.76.051922
Department(s)
Business and Information Technology
Second Department
Chemical and Biochemical Engineering
International Standard Serial Number (ISSN)
1550-2376; 1539-3755
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 American Physical Society, All rights reserved.
Publication Date
30 Nov 2007
Included in
Biochemical and Biomolecular Engineering Commons, Health Information Technology Commons, Technology and Innovation Commons
