Changes in the thiol status of neurodegenerative disorders and the effects of copper on the amyloid beta peptide clearance
"Oxidative stress is involved in the pathophysiology of certain age-associated neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). Oxidative stress in these disorders is evident by the alterations in the cellular antioxidant defense system of the brain, including glutathione and antioxidant enzymes like catalase and glutathione reductase. AD is the most common disorder affecting about two thirds of cases of dementia overall and studies indicate that oxidative stress is involved in the impairment of such functions. The amyloid beta (AB) protein has been specified as the major source of oxidative stress in the AD brain. Association of metal ions (Cu, Fe, An) in AB induced-toxicity has been noticed recently. As a mechanistic approach, we propose that upon complex formation with AB, copper might have an effect on AB clearance across the blood brain barrier"--Abstract, leaf iii.
Banks, William A.
Ph. D. in Chemistry
University of Missouri--Rolla
ix, 119 leaves
© 2006 Suneetha Mare, All rights reserved.
Dissertation - Citation
Library of Congress Subject Headings
Alzheimer's disease -- Pathophysiology
Nervous system -- Degeneration -- Research
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Link to Catalog Record
Full-text not available: Request this publication directly from Missouri S&T Library or contact your local library.http://laurel.lso.missouri.edu/record=b5947065~S5
Mare, Suneetha, "Changes in the thiol status of neurodegenerative disorders and the effects of copper on the amyloid beta peptide clearance" (2006). Doctoral Dissertations. 1710.
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