Role of glutamate in lead-induced toxicity: protection by N-acetylcysteine amide (NACA), a novel thiol antioxidant
"Despite several efforts to reduce lead levels in the environment, lead exposure continues to be a major public health problem, in the US today. Toxic effect of lead are mainly manifested in central nervous system (CNS) because brain acts as a reservoir for lead deposition. Lead-induced cell damage include glutamatergic component (excitotoxic cell damage arising from impaired clearance of the released glutamate), interference with calcium-mediated cellular processes, and activation of protein kinase C (PKC) resulting in oxidative stress. Chelation therapy has been a choice to reduce the body burden of lead; however chelation does not eliminate the neurotoxicity of lead...In this study we propose to evaluate the involvement of glutamatergic component in lead-induced toxicity and also to investigate a potential compound which counteracts the entire toxic phenomenon of lead"--Abstract, leaf iii.
Whitefield, Philip D.
Banks, William A.
Ph. D. in Chemistry
University of Missouri--Rolla
x, 89 leaves
© 2006 Suman Penugonda, All rights reserved.
Dissertation - Citation
Library of Congress Subject Headings
Glutamic acid -- Physiological effect
Lead -- Toxicology
Print OCLC #
Link to Catalog Record
Full-text not available: Request this publication directly from Missouri S&T Library or contact your local library.http://laurel.lso.missouri.edu/record=b5842234~S5
Penugonda, Suman, "Role of glutamate in lead-induced toxicity: protection by N-acetylcysteine amide (NACA), a novel thiol antioxidant" (2006). Doctoral Dissertations. 1683.