Abstract

Dendrimers exhibit super atomistic features by virtue of their well-defined discrete quantized nanoscale structures. Here, we show that hyperbranched amine-terminated polyamidoamine (PAMAM) dendrimer G4.0 reacts with linear polyethylene glycol (PEG) diacrylate (575 g/mol) via the aza-Michael addition reaction at a subzero temperature (-20 °C), namely cryo-aza-Michael addition, to form a macroporous superelastic network, i.e., dendrimer cryogel. Dendrimer cryogels exhibit biologically relevant Young's modulus, high compression elasticity and super resilience at ambient temperature. Furthermore, the dendrimer cryogels exhibit excellent rebound performance and do not show significant stress relaxation under cyclic deformation over a wide temperature range (-80 to 100 °C). The obtained dendrimer cryogels are stable at acidic pH but degrade quickly at physiological pH through self-triggered degradation. Taken together, dendrimer cryogels represent a new class of scaffolds with properties suitable for biomedical applications.

Department(s)

Chemical and Biochemical Engineering

Comments

This work was supported, in part, by the National Institutes of Health (R01EY024072).

Keywords and Phrases

dendrimer; macrogol; PAMAM Starburst; poly(ethylene glycol)diacrylate; polyamidoamine; polyamine, chemistry; cryogel; drug therapy; elasticity; human; porosity; tissue engineering, Cryogels; Dendrimers; Elasticity; Humans; Polyamines; Polyethylene Glycols; Porosity; Tissue Engineering

International Standard Serial Number (ISSN)

2045-2322

Document Type

Article - Journal

Document Version

Final Version

File Type

text

Language(s)

English

Rights

© 2018 The Authors, All rights reserved.

Publication Date

01 Dec 2018

PubMed ID

29740011

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