Title

Low-Cost Solution for Optical NMR Hyperpolarization

Presenter Information

Lucas Albrecht

Department

Chemistry

Major

Chemistry

Research Advisor

Woelk, Klaus

Advisor's Department

Chemistry

Funding Source

Ozark Biomedical Institute & Materials Research Foundation

Abstract

Hyperpolarization can boost the low sensitivity of NMR spectroscopy and medical MRI, making it possible to record spectra of samples too dilute for standard NMR analyses. A laser excitation system for optical hyperpolarization is introduced, where the beam of a low-cost 350-nm laser, controlled by a homebuilt shutter, is coupled into the sample by a multimode fiber. A modified 5-mm Shigemi tube accommodates the sample at the end of the fiber. The NMR pulse program sends a signal to a microcontroller that then operates the shutter. Irradiation and spectrum acquisition are synchronized, which also minimizes undesirable photobleaching. The new hyperpolarization system is smaller and less expensive than previously reported systems. A standard shutter costs over $2,000 while the microcontroller and fiber coupler sleeve total $85.35 (cost reduction of 96%). Spectra obtained with the new shutter setup provide an attractive solution for enhancing NMR signals in optical hyperpolarization experiments.

Biography

Lucas Albrecht is from St. Louis, Missouri. He has a passion for chemistry and has a background in chemical engineering. He joined Dr. Woelk’s research team in March 2019 and has contributed to the design of the NMR apparatus and to the oral presentation on the apparatus. His goal is to enter into a chemical industry, and design a controllable, multi-purpose nanostructure. He is currently participating as an officer in the student led chapter of the ACS, the W.T. Schrenk Society, which is active in community outreach, solving global chemical problems, and inspiring an interest in chemistry to young Americans.

Research Category

Sciences

Presentation Type

Poster Presentation

Document Type

Poster

Location

Upper Atrium

Presentation Date

16 Apr 2019, 9:00 am - 3:00 pm

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Apr 16th, 9:00 AM Apr 16th, 3:00 PM

Low-Cost Solution for Optical NMR Hyperpolarization

Upper Atrium

Hyperpolarization can boost the low sensitivity of NMR spectroscopy and medical MRI, making it possible to record spectra of samples too dilute for standard NMR analyses. A laser excitation system for optical hyperpolarization is introduced, where the beam of a low-cost 350-nm laser, controlled by a homebuilt shutter, is coupled into the sample by a multimode fiber. A modified 5-mm Shigemi tube accommodates the sample at the end of the fiber. The NMR pulse program sends a signal to a microcontroller that then operates the shutter. Irradiation and spectrum acquisition are synchronized, which also minimizes undesirable photobleaching. The new hyperpolarization system is smaller and less expensive than previously reported systems. A standard shutter costs over $2,000 while the microcontroller and fiber coupler sleeve total $85.35 (cost reduction of 96%). Spectra obtained with the new shutter setup provide an attractive solution for enhancing NMR signals in optical hyperpolarization experiments.