Title

Power Combos: Antibody Conjugated Drug Nanorods and T Cell Therapy for Breast Cancer Treatment

Presenter Information

James Schuchard

Department

Chemical and Biochemical Engineering

Major

Chemical Engineering

Research Advisor

Barua, Sutapa

Advisor's Department

Chemical and Biochemical Engineering

Abstract

The purpose of this proposal is to explore a complementary combination of two promising treatments of breast cancer. Nanoparticles are appearing as an increasingly favorable approach for non-invasive and targeted delivery of therapeutic agents to breast tumor tissues. However, there are significant challenges in the delivery of nanoparticles to the target tissue. Another exploratory approach to breast cancer treatment is to activate a patient’s own immune system to attack the tumor. Specialized cells known as T cells have been shown in some cases to recognize tumor antigen and initiate systemic immune responses in the body that destroy tumor cells. While this approach shows promise, it often lacks the potency necessary for complete treatment. I want to explore a combined approach that utilizes the direction of a patient’s T-cells as well as the potency of nanoparticles of trastuzumab-conjugated camptothecin by anchoring the nanoparticles to the surface of the T-cells.

Biography

James Schuchard is an active scholar as well as an involved and impactful member of the Missouri S&T student culture. He excels academically and has been awarded the Excellence, Curators, and University scholarships by his school and the James Johnson Scholarship by the Chemical Engineering department. He contributes to the department as a Peer Learning Assistant and grader for Materials and Energy Balances. He serves Missouri S&T through involvement in Christian Campus Fellowship and Kappa Kappa Psi honorary band fraternity in which he served as Service Committee Chair.

Research Category

Engineering

Presentation Type

Poster Presentation

Document Type

Poster

Location

Upper Atrium/Hall

Start Date

4-11-2017 1:00 PM

End Date

4-11-2017 3:00 PM

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Apr 11th, 1:00 PM Apr 11th, 3:00 PM

Power Combos: Antibody Conjugated Drug Nanorods and T Cell Therapy for Breast Cancer Treatment

Upper Atrium/Hall

The purpose of this proposal is to explore a complementary combination of two promising treatments of breast cancer. Nanoparticles are appearing as an increasingly favorable approach for non-invasive and targeted delivery of therapeutic agents to breast tumor tissues. However, there are significant challenges in the delivery of nanoparticles to the target tissue. Another exploratory approach to breast cancer treatment is to activate a patient’s own immune system to attack the tumor. Specialized cells known as T cells have been shown in some cases to recognize tumor antigen and initiate systemic immune responses in the body that destroy tumor cells. While this approach shows promise, it often lacks the potency necessary for complete treatment. I want to explore a combined approach that utilizes the direction of a patient’s T-cells as well as the potency of nanoparticles of trastuzumab-conjugated camptothecin by anchoring the nanoparticles to the surface of the T-cells.