Title

Development of novel indirect radiation damage- proof nanoparticles

Presenter Information

Hannah Kim

Department

Biological Sciences

Major

Biological Sciences, minor in Biomedical Engineering

Research Advisor

Barua, Sutapa

Advisor's Department

Chemical and Biochemical Engineering

Funding Source

Opportunities for Undergraduate Research Experiences (OURE), NASA- Missouri Space Grant Consortium (MOSGC)

Abstract

Space medications help prevent astronauts from being ill and provide acute treatment in medical emergency situation to fulfill the primary goal of a successful long duration space mission: maintaining astronauts’ health in a unique, isolated, and extreme space environment. However, recently, National Aeronautics and Space Administration (NASA) have reported a shorter shelf life of space medications caused by chronic ionizing radiation and its long term efficacy in space became questionable. Hence, to help extend the space medications’ stability and protect pharmaceuticals from the radiation damage, free radical scavenging antioxidants were bio-conjugated on the surface of drug encapsulated biocompatible nanoparticles to create a novel indirect radiation damage-proof nanoparticle. Radiation induced highly reactive free radicals, hydroxyl radicals, will be eliminated by antioxidants before it could react with the pharmaceuticals in the nanoparticle’s core. Hydroxyl radical scavenging capacity assay (HOSC) was performed to test designed nanoparticles and selected antioxidant’s free radical quenching ability.

Biography

Hannah Kim is a senior majoring in Biological Sciences with minor in Biomedical Engineering. Her research interests include nanoparticle synthesis for drug delivery, microbiology, and genetic engineering. Hannah hopes to build on her interest in biomedical engineering research and development career. She is also involved in Missouri S&T Chamber orchestra as first violin.

Research Category

Engineering

Presentation Type

Poster Presentation

Document Type

Poster

Location

Upper Atrium/Hall

Start Date

4-11-2017 1:00 PM

End Date

4-11-2017 3:00 PM

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Apr 11th, 1:00 PM Apr 11th, 3:00 PM

Development of novel indirect radiation damage- proof nanoparticles

Upper Atrium/Hall

Space medications help prevent astronauts from being ill and provide acute treatment in medical emergency situation to fulfill the primary goal of a successful long duration space mission: maintaining astronauts’ health in a unique, isolated, and extreme space environment. However, recently, National Aeronautics and Space Administration (NASA) have reported a shorter shelf life of space medications caused by chronic ionizing radiation and its long term efficacy in space became questionable. Hence, to help extend the space medications’ stability and protect pharmaceuticals from the radiation damage, free radical scavenging antioxidants were bio-conjugated on the surface of drug encapsulated biocompatible nanoparticles to create a novel indirect radiation damage-proof nanoparticle. Radiation induced highly reactive free radicals, hydroxyl radicals, will be eliminated by antioxidants before it could react with the pharmaceuticals in the nanoparticle’s core. Hydroxyl radical scavenging capacity assay (HOSC) was performed to test designed nanoparticles and selected antioxidant’s free radical quenching ability.