Title

Development of Novel Polymer Membrane Fabrication Process for Intelligent Biosensors

Presenter Information

John Bartow

Department

Chemical and Biochemical Engineering

Major

Chemical Engineering

Research Advisor

Henthorn, David

Advisor's Department

Chemical and Biochemical Engineering

Funding Source

Missouri S&T Opportunities for Undergraduate Research Experiences (OURE) Program

Abstract

In recent years, there has been an effort to develop self-calibrating electrochemical biosensors that require minimal human intervention. The overall goal of this project is to develop an implantable microchip capable of continuously monitoring blood glucose levels. Detection of glucose will be accomplished indirectly by measuring the fluorescence of europium tetracycline (EuTc) in the presence of hydrogen peroxide, a product of the reaction between glucose and glucose oxidase. One challenge of using EuTc arises from the fact that it is sensitive to phosphate ions, necessitating the use of a polymer-based charge-mosaic membrane to separate phosphate ions from the blood stream before reaching the EuTc detection matrix. Current methods for the fabrication of such membranes are time-consuming and expensive. This project demonstrates a novel, inexpensive method of fabricating a sealed-in charge-mosaic membrane using readily-available photolithographic techniques.

Biography

John Bartow is a junior pursuing a B.S. in Chemical Engineering with an emphasis in Biochemical Engineering. He is also working toward a minor in Business. This conference is John’s first research conference and his second semester on the research project.

Research Category

Engineering

Presentation Type

Poster Presentation

Document Type

Poster

Location

Upper Atrium/Hallway

Presentation Date

08 Apr 2009, 1:00 pm - 3:00 pm

Comments

Joint project with Lucas McIntosh

This document is currently not available here.

Share

COinS
 
Apr 8th, 1:00 PM Apr 8th, 3:00 PM

Development of Novel Polymer Membrane Fabrication Process for Intelligent Biosensors

Upper Atrium/Hallway

In recent years, there has been an effort to develop self-calibrating electrochemical biosensors that require minimal human intervention. The overall goal of this project is to develop an implantable microchip capable of continuously monitoring blood glucose levels. Detection of glucose will be accomplished indirectly by measuring the fluorescence of europium tetracycline (EuTc) in the presence of hydrogen peroxide, a product of the reaction between glucose and glucose oxidase. One challenge of using EuTc arises from the fact that it is sensitive to phosphate ions, necessitating the use of a polymer-based charge-mosaic membrane to separate phosphate ions from the blood stream before reaching the EuTc detection matrix. Current methods for the fabrication of such membranes are time-consuming and expensive. This project demonstrates a novel, inexpensive method of fabricating a sealed-in charge-mosaic membrane using readily-available photolithographic techniques.