Certain cyclodextrins exhibit a diminishing solubility in water when heated. This phenomena of cloud point precipitation in conjunction with cyclodextrin's ability to form an inclusion complex with many compounds, can be used as a method of chemical separation. These cyclodextrins can be removed from the solution after precipitation by a hot filtration technique and the remaining solution analyzed by HPLC. Enantiomeric separations, concentration of compounds and removal of hazardous organic materials are all possible applications of cloud point extraction using cyclodextrins.
Schmid, Deanna L., "Enantiomeric Separation by Cloud Point Precipitation of Cyclodextrins" (1991). Opportunities for Undergraduate Research Experience Program (OURE). 149.