The pore geometry of bioactive glass scaffolds intended for use in bone repair or replacement is one of the most important parameters that could determine the rate of bone regeneration. The pore geometry would also affect the mechanical properties of the scaffolds and their rate of degradation. Scaffolds with five different architectures, having ~50% porosity, were fabricated with silicate (13–93) and borate (13–93B3) based bioactive glasses using a laser sintering process. An established, late-osteoblasts/early-osteocytes cell line was used to perform cell proliferation tests on the scaffolds. The results indicated that the cells proliferate significantly more on the scaffolds which mimic the trabecular bone architecture compared to traditional lattice structures.
K. C. Kolan et al., "In Vitro Assessment of Laser Sintered Bioactive Glass Scaffolds with Different Pore Geometries," Proceedings of the 25th Annual International Solid Freeform Fabrication Symposium (2014, Austin, TX), pp. 1031-1041, University of Texas at Austin, Aug 2014.
25th Annual International Solid FreeForm Fabrication Symposium (2014: Aug. 4-6, Austin, TX)
Mechanical and Aerospace Engineering
Materials Science and Engineering
Article - Conference proceedings
06 Aug 2014