Abstract

The porosity and architecture of bone scaffolds, intended for use in bone repair or replacement, are two of the most important parameters in the field of bone tissue engineering. The two parameters not only affect the mechanical properties of the scaffolds but also aid in determining the amount of bone regeneration after implantation. Scaffolds with five different architectures and four porosity levels were fabricated using borate bioactive glass (13-93B3) using the selective laser sintering (SLS) process. The pore size of the scaffolds varied from 400 to 1300 μm. The compressive strength of the scaffolds varied from 1.7 to 15.5 MPa for porosities ranging from 60 to 30%, respectively, for the different architectures. Scaffolds were soaked in a simulated body fluid (SBF) for one week to measure the variation in mechanical properties. The formation of the Hydroxyapatite and in-vitro results are provided and discussed.

Meeting Name

24th Annual International Solid Freeform Fabrication Symposium -- An Additive Manufacturing Conference (2013: Aug. 12-14, Austin, TX)

Department(s)

Mechanical and Aerospace Engineering

Second Department

Materials Science and Engineering

Comments

The authors thankfully acknowledge Mo-Sci Corp., Rolla, MO., for kindly supplying the 13-93B3 borate bioactive glass used in this work.

Keywords and Phrases

3D printers; Architecture; Bioactive glass; Bone; Compressive strength; Laser heating; Manufacture; Mechanical properties; Porosity; Bone regeneration; Bone scaffolds; Bone tissue engineering; Borate glass; Porosity level; Selective laser sintering; Simulated body fluids; Two parameter; Scaffolds (biology)

Document Type

Article - Conference proceedings

Document Version

Final Version

File Type

text

Language(s)

English

Publication Date

14 Aug 2013

Download

Share

 
COinS