Glass Formation and Chemical Durability of Dysprosium Lithium Borate Glasses Intended for in Vivo Radiation Synovectomy
The glass formation and structure/property relationships for Dy2O3-Li2O-B2O3 glasses were investigated. Such glasses are currently being considered for in vivo radiation delivery vehicles. Chemical dissolution tests were conducted in simulated synovial fluid (pH 7.4, at 37°C, for 11 d) to evaluate the release of dysprosium from selected glasses. The chemical durability, Tg, nD and density increased as either the Li2O or Dy2O3 content in a glass was increased. Such property trends are attributed to increased crosslinking within the glass structure as BO3 triangles are converted to BO4 tetrahedra. A proposed structural model assumes dysprosium is incorporated into the glass with a coordination number of eight and is surrounded by four BO4 tetrahedra. Glasses containing ≥ 1.0 mol% Dy2O3 released less than 0.1% of their initial dysprosium content after being immersed in simulated synovial fluid for 11 d at 37°C. These glasses are considered safe for in vivo radiation delivery from the standpoint of radiation release, since dysprosium will be the only radioisotope in the glass during treatment.
S. D. Conzone et al., "Glass Formation and Chemical Durability of Dysprosium Lithium Borate Glasses Intended for in Vivo Radiation Synovectomy," Glass Science and Technology: Glastechnishche Berichte, Elsevier, Feb 2000.
Materials Science and Engineering
Keywords and Phrases
Crosslinking; Durability; Dysprosium Compounds; Dysprosium Lithium Borate; Glass; Glass Formation; Glass Structure; Glass Transition; Materials Testing; Radiation Synovectomy
Article - Journal
© 2000 Elsevier, All rights reserved.
01 Feb 2000