Strength of Hollow Hydroxyapatite Microspheres Prepared by a Glass Conversion Process
Hollow hydroxyapatite (HA) microspheres (diameter = 100-800 μm) were prepared by reacting solid Li2O-CaO-B2O3 glass spheres in 0.25 M K2HPO4 solution at 37°C. The influence of subsequent heating on the microstructure, surface area, and compressive strength of the HA microspheres was evaluated using scanning electron microscopy, the BET method, and nano-mechanical testing. The surface area and rupture strength of the as-prepared microspheres were 135 m2/g and 1.6 ± 0.6 MPa, respectively. On heating for 8 h at 600°C, the surface area decreased to 27 m2/g, but there was no increase in the compressive strength (1.7 ± 0.4 MPa). Heating to 800°C (8 h) resulted in a marked decrease in the surface area (to 2.6 m2/g) and a sharp increase in the compressive strength (to >35 ± 8 MPa). These hollow HA microspheres may be useful as devices for drug or protein growth factor delivery or as scaffolds for engineered tissues.
W. Huang et al., "Strength of Hollow Hydroxyapatite Microspheres Prepared by a Glass Conversion Process," Journal of Materials Science: Materials in Medicine, Springer Verlag, Jan 2009.
The definitive version is available at https://doi.org/10.1007/s10856-008-3554-7
Materials Science and Engineering
Keywords and Phrases
Comprehensive Strength; Hydroxyapatite
International Standard Serial Number (ISSN)
Article - Journal
© 2009 Springer Verlag, All rights reserved.
01 Jan 2009