Effective regeneration of bone defects caused by trauma or chronic diseases is a significant clinical challenge. Bone deficiency is overcome using treatments that rely on bone regeneration and augmentation. While various treatments have been investigated with encouraging results, complete and predictable bone reconstruction is often difficult [1]. Synthetic bone grafts have advantages such as consistent quality, safety, and good tissue tolerance. They usually function as inert or osteoconductive implants. Encouraging results from synthetic grafts have been reported. For instance, hollow hydroxyapatite (HA) microspheres showed the ability to facilitate bone repair in rats with non-healing calvarial defects [2,3]. However, new bone formation with the closed HA microspheres was limited. Our goal is to investigate whether open HA microsphere mediated bone repair and regeneration in an osseous model is more effective than repair mediated by closed HA microspheres. The microgeometry-, size-, and time-dependent effects of bone repair by closed and open microspheres are also compared.

Meeting Name

42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence (2019: Apr. 3-6, Seattle, WA)


Materials Science and Engineering

Second Department

Biological Sciences

Keywords and Phrases

Defects; Hydroxyapatite; Microspheres; Rats; Repair, Bone reconstruction; Consistent quality; Geometric effects; Hydroxyapatite microspheres; Regeneration of bone defects; Sprague-Dawley rats; Synthetic bone grafts; Time-dependent effects, Bone

International Standard Book Number (ISBN)


International Standard Serial Number (ISSN)


Document Type

Article - Conference proceedings

Document Version

Final Version

File Type





© 2019 Omnipress, All rights reserved.

Publication Date

01 Apr 2019