Bioactive glasses have been developed for medical applications in the body for bone and tissue repair and regeneration. We have developed a borate-containing bioactive glass (13-93B3, referred to as B3), which is undergoing clinical trials to assess its wound-healing properties. To complement the healing properties of B3, metal ion dopants have been added to enhance its antimicrobial properties. Bioactive glasses doped with silver, gallium or iodine ions were found to have broad spectrum antimicrobial effects on clinically relevant bacteria including MRSA. While the B3 glass alone was sufficient to produce antibacterial effects on select bacteria, adding dopants enhanced the broad-spectrum antibacterial properties: Live-Dead staining fluorescence microscopy suggests cell membrane integrity is disrupted in gram positive bacteria exposed to the glass compounds, but not gram negative bacteria, indicating multiple mechanisms of action for each glass formulation.
M. Ottomeyer et al., "Broad-Spectrum Antibacterial Characteristics of Four Novel Borate-Based Bioactive Glasses," Advances in Microbiology, vol. 6, no. 10, pp. 776 - 787, Scientific Research, Sep 2016.
The definitive version is available at https://doi.org/10.4236/aim.2016.610076
Materials Science and Engineering
Keywords and Phrases
Bioactive Glass; Antibacterial Properties; Metal Ions
International Standard Serial Number (ISSN)
Article - Journal
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01 Sep 2016