Influence of Cu Doping in Borosilicate Bioactive Glass and the Properties of its Derived Scaffolds


Copper doped borosilicate glasses (BG-Cu) were studied by means of FT-IR, Raman, UV-vis and NMR spectroscopies to investigate the changes that appeared in the structure of borosilicate glass matrix by doping copper ions. Micro-fil and immunohistochemistry analysis were applied to study the angiogenesis of its derived scaffolds in vivo. Results indicated that the Cu ions significantly increased the B-O bond of BO4 groups at 980 cm-1, while they decrease that of BO2O- groups at 1440-1470 cm-1 as shown by Raman spectra. A negative shift was observed from 11B and 29Si NMR spectra. The 11B NMR spectra exhibited a clear transformation from BO3 into BO4 groups, caused by the agglutination effect of the Cu ions and the charge balance of the agglomerate in the glass network, leading to a more stable glass network and lower ions release rate in the degradation process. Furthermore, the BG-Cu scaffolds significantly enhanced blood vessel formation in rat calvarial defects at 8 weeks post-implantation. Generally, it suggested that the introduction of Cu into borosilicate glass endowed glass and its derived scaffolds with good properties, and the cooperation of Cu with bioactive glass may pave a new way for tissue engineering.


Materials Science and Engineering

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Article - Journal

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© 2016 Elsevier Ltd, All rights reserved.

Publication Date

01 Jan 2016