Masters Theses

Author

Nada Abokefa

Abstract

"Bioactive glasses have been widely used in several biomedical and tissue engineering applications since the late 1960s. Numerous families of bioactive glasses have emerged over the years, with each having its own advantage and disadvantage. One concern common to all families is that most bioactive glasses create a basic or acidic environment when degraded and, therefore, are toxic for cells. Recently, there has been an increased interest in borophosphate bioactive glass (BPBGs) because of their neutral pH, release of therapeutic ions, and biodegradable properties. Despite the growing interest, there is little reported on the bioactivity of BPBGs. The biological effects of a novel series of BPBG were investigated in these studies. BPBGs were tested on human adipose stem cells (ASCs) and endothelial cells (ECs) and evaluated for viability, d ifferentiation, migration, secretome activity, and angiogenesis. The results showed that some of the BPBG compositions created a neutral pH environment and thus, showed a high level of cell viability in direct contact under normal static conditions in vitro. Moreover, some of the BPBG compositions increased angiogenesis and altered the ASCs secretome. These results indicate that each of the BPBG compositions have a specific therapeutic pattern with a significant potential in the clinical and biomedical applications"--Abstract, page iv.

Advisor(s)

Semon, Julie A.

Committee Member(s)

Huang, Yue-Wern
Shannon, Katie

Department(s)

Biological Sciences

Degree Name

M.S. in Applied and Environmental Biology

Sponsor(s)

Kuwait Petroleum Corporation (KPC)
Kuwait Oil Company (KOC)

Publisher

Missouri University of Science and Technology

Publication Date

Spring 2021

Journal article titles appearing in thesis/dissertation

  • Adipose stem cell response to borophosphate bioactive glass
  • The angiogenic potential of pH neutral borophosphate bioactive glasses

Pagination

xiii, 140 pages

Note about bibliography

Includes bibliographic references.

Rights

© 2021 Nada Amin Mohamed Abdelrahaman Abokefa, All rights reserved.

Document Type

Thesis - Open Access

File Type

text

Language

English

Thesis Number

T 11817

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