"Two projects are presented in this thesis; 1) a hollow core, concentrically symmetric beam splitting Michelson interferometric probe for optical coherence tomography and 2) the imaging of bioactive ceramic scaffolds using swept source optical coherence tomography. The key component of the interferometer is a compact, small diameter probe composed of a collimating lens, hollow core beam splitting tube, and a focusing lens intended to be used for endoscopic imaging. The beam splitting tube was created by sputter coating the distal endface of a finely polished thick wall capillary tube with a highly reflective gold layer. Part of the light travels through the wall of the tube is reflected by the distal endface, forming a reference arm, and part passes through the hollow core to be backscattered by the sample material, forming a sample arm. To demonstrate the functionality of the probe, cross-sectional and volumetric images of a simple sample were obtained. An additional advantage of this probe is an easily adjustable working distance. Bioactive ceramic scaffolds have been shown to possess high degrees of conversion to hydroyapatite and are currently used in a variety of biomedical applications. In an effort to enhance current research and demonstrate the feasibility of optical coherence tomography as a bioceramic imaging modality, a swept source optical coherence tomography system was employed in the imaging of a variety of ceramic bioscaffolds. In order to demonstrate the imaging capabilities of an optical coherence tomography system for imaging of ceramic bioscaffolds, images of scaffolds were compared to other imaging modalities"--Abstract, page iii.
Xiao, Hai, Dr.
Story, J. Greg
Moss, Randy Hays, 1953-
Electrical and Computer Engineering
M.S. in Electrical Engineering
Missouri University of Science and Technology. Center for Bone and Tissue Repair and Regeneration
National Institutes of Health (U.S.)
Missouri University of Science and Technology
ix, 47 pages
© 2012 Edward Henry Pienkowski, Jr., All rights reserved.
Thesis - Open Access
Optical coherence tomography
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Electronic OCLC #
Link to Catalog Record
Pienkowski, Edward Henry, "Optical coherence tomography for biomedical imaging" (2012). Masters Theses. 6868.