Masters Theses
Keywords and Phrases
Bub2
Abstract
"Cytokinesis is an important step to finish cell cycle events and separate into two daughter cells. This event is driven by actomyosin ring contraction. In budding yeast, the mitotic exit network (MEN) controls completion of ana/telophase by signaling events. Bub2 is a mitotic exit network regulator and binds to Tem1p which is an important component in MEN. Mad2 is a component of a separate spindle checkpoint. Mad2 dependent pathway prevents the metaphase to anaphase transition under spindle damage. Because yeast cells have cell walls, septum formation follows actin ring contraction. Here it was investigated how microtubule defects affect cytokinesis in budding yeast. It was examined various mutant cells. Data shows that, bub2 deletion or overexpression leads to a higher rate of myosin contraction. Moreover, these mutants showed chain morphology after depolymerizaion of microtubules by nocodazole. This phenomenon is caused by cell septation defects not cell cytokinesis defects"--Abstract, page iii.
Advisor(s)
Shannon, Katie
Committee Member(s)
Mormile, Melanie R.
Henthorn, David
Department(s)
Biological Sciences
Degree Name
M.S. in Applied and Environmental Biology
Publisher
Missouri University of Science and Technology
Publication Date
Summer 2008
Pagination
viii, 41 pages
Rights
© 2008 Su Young Park, All rights reserved.
Document Type
Thesis - Open Access
File Type
text
Language
English
Subject Headings
Actomyosin
Cytokinesis
Microtubules
Thesis Number
T 9414
Print OCLC #
299054314
Electronic OCLC #
299054379
Link to Catalog Record
Recommended Citation
Park, Su Young, "Role of microtubules in budding yeast cytokinesis" (2008). Masters Theses. 4641.
https://scholarsmine.mst.edu/masters_theses/4641