"This project consisted of two parts focused on in vivo evaluation of microfibrous bioactive borate glasses for use in wound healing. Part one of the project involved subcutaneous implantation of two types of borate glass microfibers and 45S5 glass micro fibers in the dorsum of rats and histologically evaluating the soft tissues at the implant sites at 2 to 4 weeks post surgery. The primary objective was to assess the angiogenic response to the implanted materials. The 13-93B3 and 13-93B3Cu glass microfibers were found to significantly increase the microvascular density in soft tissue, an outcome that suggests these simple and easily fabricated materials can be very effective for accelerating the healing of soft tissue wounds. A second objective of part one was to evaluate the possible systemic cytotoxicity of materials released from borate glass microfibers. Histological evaluation of kidney tissue from animals subcutaneously implanted with high amounts of 13-93B3 glass microfibers showed no evidence of pathological changes in the kidney. Part Two of the project involved testing the use of four types of bioactive glass microfibers for bone repair in a rat calvarial defect model. Four mm diameter defects were filled with microfibers of 45S5, 13-93B3, 13-93B3 with 0.4 wt% Cu, and CSZ glass or left empty as sham control. At 8 and 12 weeks after implantation, the calvaria were recovered for analysis. The 13-93B3Cu and CSZ glass microfibers were found to promote modestly higher amounts of bone tissue formation in critical size defects in the calvaria of rats compared with effects of 45S5 glass micro fibers and blank sham control defects. The positive outcome observed suggests these relatively simple inexpensive materials may potentially be useful as stable, readily useable materials for augmented healing of wounds both in soft tissue and hard tissue"--Abstract, page iv.
Brown, Roger F.
Day, D. E.
M.S. in Biological Sciences
Missouri University of Science and Technology
Journal article titles appearing in thesis/dissertation
- Assessment of angiogenic effects of borate glass microfibers in rat subcutaneous tissue.
- Evaluation of borate glass microfibers for repair of calvarial defects in rats
x, 75 pages
© 2012 Yinan Lin, All rights reserved.
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Electronic access to the full-text of this document is restricted to Missouri S&T users. Otherwise, request this publication directly from Missouri S&T Library or contact your local library.http://merlin.lib.umsystem.edu:80/record=b9552596~S5
Lin, Yinan, "In vivo evaluation of microfibrous bioactive borate glasses for use in wound healing" (2012). Masters Theses. 4527.
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