"Bioactive glasses with antimicrobial properties can be implemented as coatings on medical devices and implants, as well as a treatment for tissue repair and prevention of common hospital-acquired infections such as MRSA A borate-containing glass, B3, is also undergoing clinical trials to assess wound-healing properties. The sensitivities of various bacteria to B3, B3-Ag, B3-Ga, and B3-I bioactive glasses were tested. In addition, the mechanism of action for the glasses was studied by spectroscopic enzyme kinetics experiments, Live-Dead staining fluorescence microscopy, and luminescence assays using two gene fusion strains of Escherichia coli.
It was found that gram-positive bacteria were more sensitive to all four glasses than gram negative bacteria, and that a single mechanism of action for the glasses is unlikely, as the rates of catalysis for metabolic enzymes as well as membrane permeability were altered after glass exposure "--Abstract, page iii.
Westenberg, David J.
Day, D. E.
Mormile, Melanie R.
M.S. in Applied and Environmental Biology
Missouri University of Science and Technology
viii, 48 pages
© 2013 Megan Ottomeyer, All rights reserved.
Thesis - Restricted Access
Glass in medicine
Anti-infective agents -- Research
Print OCLC #
Electronic OCLC #
Link to Catalog Record
Electronic access to the full-text of this document is restricted to Missouri S&T users. Otherwise, request this publication directly from Missouri S&T Library or contact your local library.http://merlin.lib.umsystem.edu:80/record=b10115813~S5
Ottomeyer, Megan, "Broad-spectrum antibacterial properties of metal-ion doped borate bioactive glasses for clinical applications" (2013). Masters Theses. 4467.
Share My Thesis If you are the author of this work and would like to grant permission to make it openly accessible to all, please click the button above.