Masters Theses
Abstract
"Bioactive glasses with antimicrobial properties can be implemented as coatings on medical devices and implants, as well as a treatment for tissue repair and prevention of common hospital-acquired infections such as MRSA A borate-containing glass, B3, is also undergoing clinical trials to assess wound-healing properties. The sensitivities of various bacteria to B3, B3-Ag, B3-Ga, and B3-I bioactive glasses were tested. In addition, the mechanism of action for the glasses was studied by spectroscopic enzyme kinetics experiments, Live-Dead staining fluorescence microscopy, and luminescence assays using two gene fusion strains of Escherichia coli.
It was found that gram-positive bacteria were more sensitive to all four glasses than gram negative bacteria, and that a single mechanism of action for the glasses is unlikely, as the rates of catalysis for metabolic enzymes as well as membrane permeability were altered after glass exposure "--Abstract, page iii.
Advisor(s)
Westenberg, David J.
Committee Member(s)
Day, D. E.
Mormile, Melanie R.
Department(s)
Biological Sciences
Degree Name
M.S. in Applied and Environmental Biology
Publisher
Missouri University of Science and Technology
Publication Date
Spring 2013
Pagination
viii, 48 pages
Note about bibliography
Includes bibliographical references (pages 44-47).
Rights
© 2013 Megan Ottomeyer, All rights reserved.
Document Type
Thesis - Restricted Access
File Type
text
Language
English
Subject Headings
Glass in medicine
Bioactive compounds
Anti-infective agents -- Research
Thesis Number
T 10331
Print OCLC #
860991287
Electronic OCLC #
908945618
Link to Catalog Record
Electronic access to the full-text of this document is restricted to Missouri S&T users. Otherwise, request this publication directly from Missouri S&T Library or contact your local library.
http://merlin.lib.umsystem.edu:80/record=b10115813~S5Recommended Citation
Ottomeyer, Megan, "Broad-spectrum antibacterial properties of metal-ion doped borate bioactive glasses for clinical applications" (2013). Masters Theses. 4467.
https://scholarsmine.mst.edu/masters_theses/4467
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