"Bioactive glasses with antimicrobial properties can be implemented as coatings on medical devices and implants, as well as a treatment for tissue repair and prevention of common hospital-acquired infections such as MRSA A borate-containing glass, B3, is also undergoing clinical trials to assess wound-healing properties. The sensitivities of various bacteria to B3, B3-Ag, B3-Ga, and B3-I bioactive glasses were tested. In addition, the mechanism of action for the glasses was studied by spectroscopic enzyme kinetics experiments, Live-Dead staining fluorescence microscopy, and luminescence assays using two gene fusion strains of Escherichia coli.
It was found that gram-positive bacteria were more sensitive to all four glasses than gram negative bacteria, and that a single mechanism of action for the glasses is unlikely, as the rates of catalysis for metabolic enzymes as well as membrane permeability were altered after glass exposure "--Abstract, page iii.
Westenberg, David J.
Day, D. E.
Mormile, Melanie R.
M.S. in Applied and Environmental Biology
Missouri University of Science and Technology
viii, 48 pages
© 2013 Megan Ottomeyer, All rights reserved.
Thesis - Restricted Access
Glass in medicine
Anti-infective agents -- Research
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Electronic access to the full-text of this document is restricted to Missouri S&T users. Otherwise, request this publication directly from Missouri S&T Library or contact your local library.http://laurel.lso.missouri.edu:80/record=b10115813~S5
Ottomeyer, Megan, "Broad-spectrum antibacterial properties of metal-ion doped borate bioactive glasses for clinical applications" (2013). Masters Theses. 4467.
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