Title

Broad-spectrum antibacterial properties of metal-ion doped borate bioactive glasses for clinical applications

Author

Megan Ottomeyer

Abstract

"Bioactive glasses with antimicrobial properties can be implemented as coatings on medical devices and implants, as well as a treatment for tissue repair and prevention of common hospital-acquired infections such as MRSA A borate-containing glass, B3, is also undergoing clinical trials to assess wound-healing properties. The sensitivities of various bacteria to B3, B3-Ag, B3-Ga, and B3-I bioactive glasses were tested. In addition, the mechanism of action for the glasses was studied by spectroscopic enzyme kinetics experiments, Live-Dead staining fluorescence microscopy, and luminescence assays using two gene fusion strains of Escherichia coli.

It was found that gram-positive bacteria were more sensitive to all four glasses than gram negative bacteria, and that a single mechanism of action for the glasses is unlikely, as the rates of catalysis for metabolic enzymes as well as membrane permeability were altered after glass exposure "--Abstract, page iii.

Advisor(s)

Westenberg, David J.

Committee Member(s)

Day, D. E.
Mormile, Melanie R.

Department(s)

Biological Sciences

Degree Name

M.S. in Applied and Environmental Biology

Publisher

Missouri University of Science and Technology

Publication Date

Spring 2013

Pagination

viii, 48 pages

Note about bibliography

Includes bibliographical references (pages 44-47).

Rights

© 2013 Megan Ottomeyer, All rights reserved.

Document Type

Thesis - Restricted Access

File Type

text

Language

English

Subject Headings

Glass in medicine
Bioactive compounds
Anti-infective agents -- Research

Thesis Number

T 10331

Print OCLC #

860991287

Electronic OCLC #

908945618

Link to Catalog Record

Electronic access to the full-text of this document is restricted to Missouri S&T users. Otherwise, request this publication directly from Missouri S&T Library or contact your local library.

Recommended Citation

Ottomeyer, Megan, "Broad-spectrum antibacterial properties of metal-ion doped borate bioactive glasses for clinical applications" (2013). Masters Theses. 4467.
https://scholarsmine.mst.edu/masters_theses/4467