A Hybrid Deep Learning and Handcrafted Feature Approach for Cervical Cancer Digital Histology Image Classification


Cervical cancer is the second most common cancer affecting women worldwide but is curable if diagnosed early. Routinely, expert pathologists visually examine histology slides for assessing cervix tissue abnormalities. A localized, fusion-based, hybrid imaging and deep learning approach is explored to classify squamous epithelium into cervical intraepithelial neoplasia (CIN) grades for a dataset of 83 digitized histology images. Partitioning the epithelium region into 10 vertical segments, 27 handcrafted image features and rectangular patch, sliding window-based convolutional neural network features are computed for each segment. The imaging and deep learning patch features are combined and used as inputs to a secondary classifier for individual segment and whole epithelium classification. The hybrid method achieved a 15.51% and 11.66% improvement over the deep learning and imaging approaches alone, respectively, with a 80.72% whole epithelium CIN classification accuracy, showing the enhanced epithelium CIN classification potential of fusing image and deep learning features.


Electrical and Computer Engineering

Second Department



National Cancer Institute, Grant None

Keywords and Phrases

Cervical Cancer; Clinical Decision Support Systems; Convolutional Neural Networks; Data Fusion; Deep Learning; Feature Extraction; Image Classification

International Standard Serial Number (ISSN)

1555-3396; 1555-340X

Document Type

Article - Journal

Document Version


File Type





© 2019 IGI Global, All rights reserved.

Publication Date

01 Apr 2019