A Study of Particle Swarm Optimization in Gene Regulatory Networks Inference

Author

Rui Xu, Missouri University of Science and TechnologyFollow
Ganesh K. Venayagamoorthy, Missouri University of Science and TechnologyFollow
Donald C. Wunsch, Missouri University of Science and TechnologyFollow

Abstract

Gene regulatory inference from time series gene expression data, generated from DNA microarray, has become increasingly important in investigating genes functions and unveiling fundamental cellular processes. Computational methods in machine learning and neural networks play an active role in analyzing the obtained data. Here, we investigate the performance of particle swarm optimization (PSO) on the reconstruction of gene networks, which is modeled with recurrent neural networks (RNN). The experimental results on a synthetic data set are presented to show the parameter effects of PSO on RNN training and the effectiveness of the proposed method in revealing the gene relations.

Recommended Citation

R. Xu et al., "A Study of Particle Swarm Optimization in Gene Regulatory Networks Inference," Advances in Neural Networks-ISNN 2006: Third International Symposium on Neural Networks, Springer-Verlag, May 2006.

Department(s)

Electrical and Computer Engineering

Keywords and Phrases

Gene Regulatory Inference; Genetic Engineering; Optimization; Particle Swarm Optimization (PSO)

Document Type

Article - Conference proceedings

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2006 Springer-Verlag, All rights reserved.

Publication Date

01 May 2006