Doctoral Dissertations

Keywords and Phrases

Organic Synthesis


"Purine-derived compounds are widely investigated as cyclin-dependent kinase inhibitors that have broad applications in the design of pharmaceuticals for treating diseases, such as diabetes, atherosclerosis, and cancers. Towards the goal of effective AGE-inhibitors, and neuroprotector compounds we have synthesized a series of novel purine-based triazoles and investigated their neuroprotective effects, using SHSY-3Y human neuroblastoma cell line. Through these studies, we have identified purine-based neuroprotector compounds that favorably modulate oxidative stress induced by the Fenton reaction-generated reactive oxygen species (ROS).

The C(sp2−H)-trifluoromethylation of hydrazones would give access to the αtrifluoromethylated hydrazones that can serve as intermediates in the synthesis of pharmaceutically interesting, fluorinated compounds. Herein, we demonstrate two different synthetic routes for the C(sp2−H)-trifluoromethylation of the aldehyde hydrazones using the readily available and cost-effective Langlois reagent (sodium trifluoromethanesulfinate). This reaction scheme is broadly applicable to a series of aromatic aldehyde N-amino morpholine hydrazones to give the corresponding C(sp2)- trifluoromethyl hydrazones in moderate to high yields. Cu (II)-catalysis provides a cost-effective synthetic approach while Rose Bengal mediated photo redox catalyzed method provides environmentally benign synthetic method for the trifluoromethylation of aldehyde hydrazones"--Abstract, p. iii


Reddy, Prakash

Committee Member(s)

Winiarz, Jeffrey G.
Choudhury, Amitava
Nam, Paul Ki-Souk
Chandrashekhara, K.



Degree Name

Ph. D. in Chemistry


Missouri University of Science and Technology

Publication Date

Fall 2022


ix, 113 pages

Note about bibliography

Includes_bibliographical_references_(pages 107-112)


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Document Type

Dissertation - Open Access

File Type




Thesis Number

T 12186