Doctoral Dissertations


"Structural DNA nanotechnology utilizes DNA molecules as building blocks to fabricate ordered artificial nanostructures at the molecular level. Among all DNA-based techniques, DNA origami has been considered as one of the most powerful tools for constructing artificial nanostructures with excellent programmability and addressability. Currently, most DNA origami nanostructures are static and do not have the ability to response to environmental stimulation. The development of environmental-responsive DNA origami nanostructures is a critical step towards the realization of intelligent dynamic DNA origami-based nanodevices. This research focuses on the design and fabrication process of both static and dynamic DNA origami nanostructures and their supported assembly of functional nanomaterials.

This research consists of three journal topics. The first topic describes the metal ion-responsive assembly/disassembly of DNA origami dimers. The association/dissociation of dimer structures is realized by using G-quadruplexes as dynamic bridges because of their facile stimulus-responsive capability induced by metal-ions, such as potassium (K+) and sodium (Na+). The second topic introduces the study of stepwise reversible assembly of DNA origami nanoclusters via pH stimulation. The association and dissociation processes are realized by the conformation changes of DNA triplex under different pH conditions. The last topic represents the fabrication of well-aligned two-dimensional AuNR arrays guided by DNA origami on solid surface. The as-fabricated nanostructures have shown promising applications in nanoelectronics, nanoplasmonics and nanophotonics"--Abstract, p. iv


Wang, Risheng

Committee Member(s)

Ercal, Nuran
Nath, Manashi
Nam, Paul Ki-souk
Huang, Yue-Wern



Degree Name

Ph. D. in Chemistry


Missouri University of Science and Technology

Publication Date

Spring 2021


x, 124 pages

Note about bibliography

Includes_bibliographical_references_(pages 120-123)


© 2021 Shuo Yang, All Rights Reserved

Document Type

Dissertation - Open Access

File Type




Thesis Number

T 12149

Included in

Chemistry Commons