"Novel small molecule inhibitors and breakers of advanced glycation end-products (AGEs) have been synthesized and their in vitro inhibitory activities have been studied by 13C NMR, fluorescence, and UV-visible spectroscopy. We have demonstrated that these AGE-inhibitors and AGE-breakers were found to be more effective in their sequestration of AGE intermediates, such as dehydroascorbate (DHA) than the state-of-the art phenacylthiazolium bromide (PTB)-based AGE-inhibitors and AGE-breakers. Citric acid and other polyphenolic antioxidants have substantial AGE inhibitory effects in the D-glucose/leucine or benzylamine Maillard reaction model systems, and thus they are suitable as dietary additives for ameliorating AGE-induced complications.
Organofluorine compounds have found numerous applications as pharmaceutically interesting compounds, and toward developing novel synthetic methods for organofluorine compounds, we have investigated synthetic strategies for gem-difluoro and trifluormethyl compounds. gem-Difluorination of 1,3-dithiolanes, obtained from the corresponding ketones, form gem-difluoromethylene compounds through the photoredox catalysis, using photocatalyst 9-fluorenone in the presence of visible light (household bulb 13W CFL). This reaction proceeds under mild conditions and is applicable to gem-difluorination of variously substituted diaryl 1,3-dithiolanes. We have also developed a novel NHC-catalyzed trifluoromethylation of aromatic N-tosyl aldimines with electron-withdrawing as well as electron-donating groups on the aryl ring. We have synthesized a series of novel purine-based triazole derivatives as potential CDK-inhibitors and characterized their structures using high-field 1H- and 13C-NMR spectroscopy”--Abstract, page iii.
Winiarz, Jeffrey G.
Ph. D. in Chemistry
Missouri University of Science and Technology
xx, 177 pages
© 2018 Jatin Mehta, All rights reserved.
Dissertation - Open Access
Mehta, Jatin, "Part I: Design, synthesis, and studies of novel age-inhibitors and age-breakers; Part II: Novel synthetic methods for organofluorine compound" (2018). Doctoral Dissertations. 3136.