Doctoral Dissertations

Author

Xianjie Qiu

Keywords and Phrases

Fluid Flow; Krogh Cylinder; Mass Transfer

Abstract

"Drug delivery to inside of the tumor is the important problem. The dynamics of drug delivery is presented here. Previously and particularly for directed delivery, a stirred tank model has been used, which appears to have worked well when compared to experiments. However, the stirred tank models do not include all the mass transfer resistances and towards that end we have used a distributed system called Krogh cylinder. This study focuses on the Krogh cylinder model simulation, both on the fluid flow and the mass transfer. The capillary network is broken down into cylindrical cells, each containing a capillary and appropriate amount of extravascular tissue. An organ is built with several of these connected in parallel. These models use the experimental data and apply many formulations, such as dynamics, through the capillary membrane, through the porous media. The result emphasizes convective mass transfer, in major disagreement with Krogh cylinder models available so far. It predicts the flow more closely to obtain a higher amount of convection in keeping with non-quantitative discussions in physiology. The equations of motion, continuity and conservation of species to obtain pressure distribution and drug distribution"--Abstract, page iv.

Advisor(s)

Neogi, P. (Partho), 1951-

Committee Member(s)

Forciniti, Daniel
Hou, Chen
Wang, Cheng
Wang, Jee-Ching

Department(s)

Chemical and Biochemical Engineering

Degree Name

Ph. D. in Chemical Engineering

Publisher

Missouri University of Science and Technology

Publication Date

Spring 2021

Journal article titles appearing in thesis/dissertation

  • Convection in a Krogh cylinder: Putting back fluid in the extravascular tissue
  • Effect of flow on mass transfer in targeted drug delivery
  • A convection transport model for transfer of solute to the extravascular tissue

Pagination

xiii, 104 pages

Note about bibliography

Includes bibliographic references.

Rights

© 2021 Xianjie Qiu, All rights reserved.

Document Type

Dissertation - Open Access

File Type

text

Language

English

Thesis Number

T 11848

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