Doctoral Dissertations


Chuan Wang


"Pharmaceutical and personal care products have benefited humans and animals around the world. However, their presence in natural and treated water system as emerging contaminates may have potentially adverse effects on the aquatic environment and cause development of bacterial resistance. In this research project, a comprehensive liquid chromatography tandem mass spectrometry method has been developed and validated for the analysis of sixteen pharmaceutical compounds using solid phase extraction. Treated and untreated water samples collected across Missouri from water treatment facilities were analyzed to access the distribution of sixteen pharmaceutical compounds in both winter and summer seasons. The results of the occurrence study indicated that these pharmaceutical compounds in different types of water resources were usually below 80 ng/L, except caffeine. It was also found that the treatment processes in water facilities were effective to remove pharmaceutical compounds in most cases. The study of pharmaceutical elimination is still crucial in providing information for the disinfection strategy in water treatment facilities. The follow-up study was performed to investigate both the treatability and elimination of eight detected pharmaceuticals in the occurrence study as a function of treatment approach, types of disinfections (free chlorine, monochloramine, ozone and permanganate ), and treatment conditions (e.g., pH, contact time, etc). The results indicated that the degradation levels of pharmaceutical compounds varied significantly in different oxidation processes. Chlorination at 1 mg/L was found to be highly effective in the elimination of the selected pharmaceuticals. The pH conditions also played an important role in pharmaceutical removal, and its effect was conditional based on the oxidation system and pharmaceutical involved"--Abstract, page iv.


Ma, Yinfa
Adams, C. D. (Craig D.)

Committee Member(s)

Whitefield, Philip D.
Nam, Paul Ki-souk
Winiarz, Jeffrey G.



Degree Name

Ph. D. in Chemistry


Missouri. Department of Natural Resources


Missouri University of Science and Technology

Publication Date


Journal article titles appearing in thesis/dissertation

  • Investigation of pharmaceutical in Missouri natural and drinking water using high performance liquid chromatography-tandem mass spectrometry.
  • Investigation of oxidative and PAC removal of selected pharmaceuticals in various oxidation systems by using liquid chromatography-tandem mass spectrometry.


x, 96 pages

Note about bibliography

Includes bibliographical references.

Geographic Coverage



© 2011 Chuan Wang, All rights reserved.

Document Type

Dissertation - Open Access

File Type




Subject Headings

Drinking water -- Drug content -- Missouri
Drinking water -- Contamination -- Missouri
Drinking water -- Purification -- Research
Liquid chromatography
Tandem mass spectrometry

Thesis Number

T 10179

Print OCLC #


Electronic OCLC #


Included in

Chemistry Commons