Doctoral Dissertations


"A significant amount of concern has emerged regarding the presence of antibiotics in the environment and the increase in antibiotic-resistant bacterial infections. This has prompted researchers to study the effects and fate of antibiotics in the environment. Little work has been conducted, however, on the effects and fate of antibiotics in anaerobic lagoons commonly used for waste treatment and storage. This work focused on the inhibition of methanogenesis by antibiotics, sorption of antibiotics to lagoon sediments, and hydrolysis, abiotic and biotic degradation of antibiotics in two central Missouri anaerobic lagoons used at two different confined animal feeding operations (CAFOs) which housed swine. Inhibition studies revealed that antibiotics commonly used in agriculture did partially inhibit methanogenesis in the two anaerobic lagoons studied. Bacitracin A, and three tetracycline, tetracycline, chlortetracycline, and oxytetracycline degraded rapidly in buffered, distilled/deionized water that was maintained at temperatures and pH's commonly encountered in the two study lagoons. However, lincomycin, several studied sulfonamides, and tylosin A were much more recalcitrant. These results do not agree in all cases with results from the abiotic degradation study where autoclaved, lagoon slurry was used. Results from the sorption study of antibiotics to lagoon sediments indicate that the sorption trends varied according to: tetracyclines> tylosin A>> lincomycin> sulfonamides"--Abstract, page iv.


Adams, C. D. (Craig D.)

Committee Member(s)

Wronkiewicz, David J.
Meyer, Michael T.
Mormile, Melanie R.
Mendoza, Cesar
Burken, Joel G. (Joel Gerard)


Civil, Architectural and Environmental Engineering

Degree Name

Ph. D. in Civil Engineering


United States. Environmental Protection Agency
U.S. Geological Survey Toxic Substances Hydrology Program--Surface-Water Contamination


Funded by the United States Environmental Protection Agency (XP-9979590 1 0)


University of Missouri--Rolla

Publication Date

Spring 2006

Journal article titles appearing in thesis/dissertation

  • Inhibition of microbial metabolism in anaerobic lagoons by selected sulfonamides, tetracyclines, lincomycin, and tylosin tartate
  • Hydrolysis of selected antibiotics and assessment of temperature, pH, and ionic strength effects on the rate of degradation
  • Sorption of six veterinary antibiotics in two Missouri anaerobic swine lagoons
  • Fate of lincomycin, oxytetracycline, sulfathiozole, and tylosin A in anaerobic swine lagoons


xiii, 123 pages

Note about bibliography

Includes bibliographical references.


© 2006 Keith Allen Loftin, All rights reserved.

Document Type

Dissertation - Restricted Access

File Type




Subject Headings

Anaerobic bacteria
Antibiotics -- Environmental aspects
Sewage lagoons

Thesis Number

T 8999

Print OCLC #


Electronic OCLC #


Link to Catalog Record

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