Doctoral Dissertations


"In this work, the dynamic and equilibrium effects of the presence of an electrical double layer on the electrically-driven mass transport mechanisms of electroosmotic flow (EOF) and electrophoretic migration, as well as the interplay of these transport mechanisms with the diffusion and adsorption mechanisms of charged and uncharged solutes in charged chromatographic media employed in capillary electrochromatography (CEC) and ion exchange systems are modeled, studied, and analyzed. The modelling of these mechanisms has put the analysis of the dynamic behavior of CEC systems to now be based on fundamental scientific understanding and, thus, the design and operation of CEC systems can now be made through engineering science. Furthermore, the modelling of these mechanisms has revolutionized our fundamental understanding of ion-exchange chromatography. For the first time it has been shown how the evolving dynamic behavior of the charge density of a solid adsorptive surface immersed in an electrolytic solution, through the electrical double layer, affects both the transport in the liquid solution and the adsorption rate of charged analytes onto the charged solid surface, and could be responsible for the generation of concentration rings in charged porous adsorbent particles, as experimentally observed by confocal scanning laser microscopy. Finally, theoretical results for the velocity of the EOF and the height equivalent of a theoretical plate (HETP) in CEC systems have been compared with experimental data and the agreement between theory and experiment is found to be good"--Abstract, page iv.


Liapis, Athanasios I.

Committee Member(s)

Crosser, Orrin K.
Leventis, Nicholas
Neogi, P. (Partho), 1951-
Avula, Xavier J. R.


Chemical and Biochemical Engineering

Degree Name

Ph. D. in Chemical Engineering


University of Missouri--Rolla. Biochemical Processing Institute
University of Missouri Research Board
Deutsche Forschungsgemeinschaft (Bonn, Germany)
Agilent Technologies (Waldbronn, Germany)


Accompanying CD-ROM, available at Missouri S&T Library, contains "original FORTRAN 90 source code that provides the solution to the mathematical models presented in the main body of the dissertation."


University of Missouri--Rolla

Publication Date

Summer 2002

Journal article titles appearing in thesis/dissertation

  • Modeling the velocity field of the electroosmotic flow in charged capillaries and in capillary columns packed with charged particles: interstitial and intraparticle velocities in capillary electrochromatography systems
  • Capillary electrochromatography: determination of the intraparticle electroosmotic volumetric flow-rate, velocity and peclet number from pore network theory
  • Film mall transfer coefficient expressions for electroosmotic flows
  • Modeling and analysis of the electrokinetic mass transport and adsorption mechanisms of a charged adsorbate in capillary electrochromatography systems employing charged non-porous adsorbent particles
  • Quantitative analysis and synthesis of the electrokinetic mass transport and adsorption mechanisms of a charged adsorbate in capillary electrochromatography systems employing charged adsorbent particles
  • Modeling and analysis of the dynamic behavior of mechanisms that result in the development of inner radial humps in the concentration of a single adsorbate in the adsorbed phase of porous adsorbent particles observed in confocal scanning laser microscopy experiments: diffusional mass transfer and adsorption in the presence of an electrical double layer
  • Interplay of diffusional and electrophoretic transport mechanisms of charged solutes in the liquid film surrounding charged non-porous adsorbent particles employed in finite bath adsorption systems
  • Novel general expressions that describe the behavior of the height equivalent of a theoretical plate in chromatographic systems involving electrically-driven and pressure-driven flows


xxvii, 546 pages; CD-ROM

Note about bibliography

Includes bibliographical references.


© 2002 Brian Arthur Grimes, All rights reserved.

Document Type

Dissertation - Restricted Access

File Type




Subject Headings

Chromatographic analysis
Capillary electrophoresis

Thesis Number

T 8627

Print OCLC #


Electronic OCLC #


Link to Catalog Record

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