Biomarker Analysis For Prostate Cancer Diagnosis using LC-MS and CE-MS

Abstract

Prostate cancer is one of the most common cancer types in men. In addition, it is the second leading cause of cancer death in the USA and Canada. Prostate cancer diagnosis is not a precise science yet. Discovery of potential biomarkers for early prostate cancer diagnosis and monitoring is crucially important. LC-MS and CE-MS have been widely used analytical techniques in the biomarker discovery. This review will describe the applications of LC-MS with different ionization techniques, such as ESI, atmospheric-pressure photoionization and atmospheric-pressure chemical ionization, and CE-MS techniques used in prostate cancer biomarker analysis.

Department(s)

Chemistry

Keywords and Phrases

6 Oxoprostaglandin F1 Alpha; 8 Hydroxydeoxyguanosine; Androstanolone; Arachidonic Acid; Atmospheric Pressure Chemical Ionization; Atmospheric Pressure Photoionization; Biological Marker; Cancer Diagnosis; Cancer Staging; Capillary; Capillary Electrophoresis; Chromatography; Creatinine; Creatinine Urine Level; Deoxyadenosines; Deoxyguanosine; Electrophoresis; Electrospray; Electrospray Ionization; Electrospray Mass Spectrometry; Gleason Score; High Performance Liquid Chromatography; High Pressure Liquid; Human; Ionization; Limit Of Detection; Liquid Chromatography; Male; Mass; Mass Spectrometry; Molecular Weight; Nonhuman; Prostaglandin D2; Prostaglandin E2; Prostaglandin F2 Alpha; Prostaglandin J2; Prostaglandins; Prostate Cancer; Prostate Specific Antigen; Prostatic Neoplasms; Sensitivity And Specificity; Spectrometry; Testosterone; Ultracentrifugation; Urinalysis

International Standard Serial Number (ISSN)

1757-6180

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2011 Future Science, All rights reserved.

Publication Date

01 Sep 2011

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