Abstract
There is a range of medical conditions, which include acute organ failure, bacterial and viral infection, and sepsis, that result in overactivation of the inflammatory response of the organism and release of proinflammatory cytokines into the bloodstream. Fast removal of these cytokines from blood circulation could offer a potentially efficient treatment of such conditions. This study aims at the development and assessment of novel biocompatible graphene-based adsorbents for blood purification from proinflammatory cytokines. These graphene-based materials were chosen on the basis of their surface accessibility for small molecules further facilitated by the interlayer porosity, which is comparable to the size of the cytokine molecules to be adsorbed. Our preliminary results show that graphene nanoplatelets (GnP) exhibit high adsorption capacity, but they cannot be used in direct contact with blood due to the risk of small carbon particle release into the bloodstream. Granulation of GnP using poly(tetrafluoroethylene) as a binder eliminated an undesirable nanoparticle release without affecting the GnP surface accessibility for the cytokine molecules. The efficiency of proinflammatory cytokine removal was shown using a specially designed flow-through system. So far, GnP proved to be among the fastest acting and most efficient sorbents for cytokine removal identified to date, outperforming porous activated carbons and porous polymers.
Recommended Citation
M. Seredych and B. Haines and V. Sokolova and P. Cheung and F. Meng and L. Stone and L. Mikhalovska and S. Mikhalovsky and V. Mochalin and Y. Gogotsi, "Graphene-Based Materials for the Fast Removal of Cytokines from Blood Plasma," ACS Applied Bio Materials, vol. 1, no. 2, pp. 436 - 443, American Chemical Society, Aug 2018.
The definitive version is available at https://doi.org/10.1021/acsabm.8b00151
Department(s)
Chemistry
Keywords and Phrases
Adsorption; Cytokines; Graphene nanoplatelets; Human blood plasma; Sepsis
International Standard Serial Number (ISSN)
2576-6422
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2024 American Chemical Society, All rights reserved.
Publication Date
20 Aug 2018
PubMed ID
35016373
Comments
National Science Foundation, Grant None