Comparison of the Selectivity and Retention of Β-Cyclodextrin vs.. Heptakis-2,3-O-Dimethyl-Β-Cyclodextrin LC Stationary Phases for Structural and Geometric Isomers

Abstract

Both β-cyclodextrin and 2,3-methylated-β-cyclodextrin bonded stationary phases effectively separate a variety of structural and geometrical isomeric compounds in the reversed phase mode. The retention of neutral structural isomeric compounds, as well as substituted phenols and anilines, was usually longer on the methylated cyclodextrin stationary phase. Conversely, the retention of all substituted carboxylic acids was greater on the native β-cyclodextrin stationary phase. The selectivity differences between the native β-cyclodextrin and its 2,3-methylated analogue were not as great as expected for the structural isomers. In general, the structural isomer that was retained longest on the native β-cyclodextrin stationary phase also was retained longest on the 2,3-methylated cyclodextrin stationary phase.

Department(s)

Chemistry

International Standard Serial Number (ISSN)

1082-6076

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2024 Taylor and Francis Group; Taylor and Francis, All rights reserved.

Publication Date

01 Jan 1997

Link to Full Text

Share

 
COinS