Characterization and Evaluation of D-(+)-Tubocurarine Chloride as a Chiral Selector for Capillary Electrophoretic Enantioseparations

Author

Usha B. Nair
Daniel W. Armstrong, Missouri University of Science and Technology
Willie L. Hinze

Abstract

A new macrocyclic of the bis(benzylisoquinoline) alkaloid family, d- (+)-tubocurarine chloride (DTC), has been evaluated as a chiral selector for the separation of optical isomers of organic carboxylates using capillary electrophoresis (CE). The pertinent physicochemical properties, such as absorption spectrum, isoionic point, and solution conformation, of DTC were determined. The effects of varying such experimental parameters as DTC concentration, pH, and methanol content in the running buffer were assessed. CE separation of the enantiomers of 18 different compounds was achieved using DTC as the chiral selector under optimized background electrolytic conditions.

Recommended Citation

U. B. Nair et al., "Characterization and Evaluation of D-(+)-Tubocurarine Chloride as a Chiral Selector for Capillary Electrophoretic Enantioseparations," Analytical Chemistry, vol. 70, no. 6, pp. 1059 - 1065, American Chemical Society, Mar 1998.

The definitive version is available at https://doi.org/10.1021/ac9708607

Department(s)

Chemistry

Comments

National Institute of General Medical Sciences, Grant R01GM053825

International Standard Serial Number (ISSN)

0003-2700

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2024 American Chemical Society, All rights reserved.

Publication Date

15 Mar 1998

PubMed ID

9529999